Publications

  • Salamzade R, Cheong JZA, Sandstrom S, Swaney MH, Stubbendieck RM, Starr NL, Currie CR, Singh AM, Kalan LR (2022) IsaBGC provides a comprehensive framework for evolutionary analysis of biosynthetic gene clusters within focal taxa. bioRxiv. 2022 June; doi: https://doi.org/10.1101/2022.04.20.488953
  • Kieft K, Adams A, Salamzade R, Kalan L, Anantharaman K (2022) vRhyme enables binning of viral genomes from metagenomes. Nucleic Acids Research. 2022 May; doi: https://doi.org/10.1093/nar/gkac341
  • Swaney MH, Kalan LR (2022) Two-for-one: Dual host-microbe functions of S. epidermidis Sph. Cell Host & Microbe. 2022 March; doi: https://doi.org/10.1016/j.chom.2022.02.011
  • Starr NL, Steidl O, Smith J, Sandstrom S, Swaney MH, Singh AM, Kalan L (2022) Culturing of Bacterial Isolates from Skin of Pediatric Atopic Dermatitis Subjects. The Journal of Allergy and Clinical Immunology. 2022 February; doi: https://doi.org/10.1016/j.jaci.2021.12.445
  • Steidl O, Starr NL, Smith J, Kalan L, Singh AM (2022) Staphylococcus aureus Disruption of Keratinocytes in Atopic Dermatitis. The Journal of Allergy and Clinical Immunology. 2022 February; doi: https://doi.org/10.1016/j.jaci.2021.12.748
  • Johnson CJ, Cheong JZA, Shanmuganayagam D, Kalan LR, Nett JE (2022) Modeling Candida auris Colonization on Porcine Skin Ex Vivo. Methods in molecular biology. 2022; doi: https://doi.org/10.1007/978-1-0716-2417-3_20
  • Swaney MH, Sandstrom S, Kalan LR (2021)  Cobamide sharing drives skin microbiome dynamics. bioRxiv. 2021 November; doi: https://doi.org/10.1101/2020.12.02.407395
  • Roesemann S, Cheong A, Tanaglia A, Brennan M, Kalan L (2021) Characterizing Host-Microbiome Interactions In Response to Sharp Debridement In Diabetic Foot Ulcers. Wound Repair and Regeneration. 2021 May
  • Cheong A, Rust C, Liu A, Kalan L, Gibson A (2021) Trade-offs Between Antiseptic Efficacy And Cytotoxicity In A Human Ex Vivo Wound Contamination Model. Wound Repair and Regeneration. 2021 May
  • Swaney MH, Kalan LR (2021) 197 Investigation of vitamin B12 sharing within the skin microbiome. Journal of Investigative Dermatology. 2021 May; doi: https://doi.org/10.1016/j.jid.2021.02.218
  • Cheong JZA, Johnson CJ, Wan H, Liu A, Kernien JF, Gibson ALF, Nett JE, Kalan LR (2021) Priority effects dictate community structure and alter virulence of fungal-bacterial biofilms. The ISME Journal. 2021 February; doi: https://doi.org/10.1038/s41396-021-00901-5
  • Swaney MH, Kalan LR (2021) Living in your Skin: Microbes, Molecules, and Mechanisms. ASM Infection and Immunity. 2021 January; doi: 10.1128/IAI.00695-20
  • Swaney MH, Kalan LR (2020) Corynebacterium Comparative Genomics Reveals a Role for Cobamide Sharing in the Skin Microbiome. bioRxiv. 2020 December; doi: https://doi.org/10.1101/2020.12.02.407395 
  • Cheong A, Johnson C, Wan H, Liu A, Kernien J, Gibson A, Nett J, Kalan LR (2020) Priority effects dictate community structure and alter virulence of fungal-bacterial biofilms. bioRxiv. 2020 August; doi: https://doi.org/10.1101/2020.08.27.267492 
  • Campbell AE, McCready-Vangi AR, Uberoi A, Kalan L, Gardner S, Grice E (2020) Staphylococcus aureus virulence acquisition and diabetic wound fate. Wound Repair and Regeneration. 2020 July.
  • Cheong A, Johnson C, Wan H, Nett J, Kalan L (2020) Investigating bacterial-fungal interactions within chronic wound microbiomes. Wound Repair and Regeneration. 2022 July.
  • Bradley CW, Lee FF, Rankin SC, Kalan LR, Horwinski J, Morris DO, Grice EA, Cain CL (2020) The otic microbiota and mycobiota in a referral population of dogs in eastern USA with otitis externa. Veterinary Dermatology. 2020 June; doi: doi.org/10.1111/vde.12826
  • Horton MV, Johnson CJ, Kernien JF, Patel TD, Lam BC, Cheong JZA, Meudt JJ, Shanmuganayagam D, Kalan LR, Nett JE (2020) Candida auris forms high-burden biofilms in skin niche conditions and on porcine skin. mSphere. 2020 January; doi: https://doi.org/10.1128/mSphere.00910-19
  • Davis SC, Solis M, Gil J, Higa A, Metzger S, and Kalan L (2019) Effects of Topical Antimicrobial Formulations on Pseudomonas aeruginosa Infection in a Porcine Burn Wound Model. bioRxiv. 2019 August; doi: https://doi.org/10.1101/737338
  • Deusenbery CB, Kalan L, Meisel M, Garder SE, Grice E, and Spiller K (2019) Human Macrophage Response to Microbial Supernatants from Diabetic Foot Ulcers. Wound Repair and Regeneration. 2019 July; doi: https://doi.org/10.1111/wrr.12752
  • Kalan LR, Meisel JS, Loesche MA, Horwinski J, Soaita I, Chen X, Uberoi A, Gardner SE, Grice EA (2019) Strain- and Species-Level Variation in the Microbiome of Diabetic Wounds Is Associated with Clinical Outcomes and Therapeutic Efficacy. Cell Host & Microbe. 2019 May; doi: 10.1016/j.chom.2019.03.006
  • Uberoi A, Campbell A, Kalan L, Lovins V, White E, Gardener S, Grice EA (2019) 940 Epithelial-microbial crosstalk modifies wound healing outcomes: from shotgun metagenomics to mechanistic understanding. Journal of Investigative Dermatology. 2019 May; doi: https://doi.org/10.1016/j.jid.2019.03.1016
  • Gibson A, Garren A, Metzger S, Kalan L (2019) MONITORING OF BIOFILM FORMATION IN BURN WOUNDS IN REAL-TIME. Wound Repair and Regeneration. 2019 May. 
  • Cheong JZA, and Kalan LR (2019) Wound microbiome update: sequencing and behavior. Wounds International. 2019; https://www.akademie-zwm.ch/uploads/media/konsensusdokumente/Wound_microbiome_update_sequencing_and_behaviour_WOUNDS_2019.pdf
  • Kalan LR, Brennan MB (2018) The role of the microbiome in nonhealing diabetic wounds. Annals of the New York Academy of Sciences. 2018 July; doi: https://doi.org/10.1111/nyas.13926
  • Kalan L, Grice EA (2018) Fungi in the wound microbiome. Advances in Wound Care. 2018 July; doi: https://doi.org/10.1089/wound.2017.0756
  • Kalan L, Zhou M, Labbie M, Willing B (2017) Measuring the microbiome of chronic wounds with use of a topical antimicrobial dressing – A feasibility study. PLoS ONE. 2017 November; doi: https://doi.org/10.1371/journal.pone.0187728
  • Kalan L, Loesche M, Gardner S, Grice E (2017) APPLICATION OF SHOTGUN METAGENOMICS TO STUDY MULTI-KINGDON MICROBIAL COMMUNITIES OF CHRONIC NONHELAING WOUNDS AND THEIR ASSOCIATION WITH CLINICAL OUTCOMES. Wound Repair and Regeneration. 2017 July. 
  • Kalan LR, Pepin DM, Ul-Haq I, Miller SB, Hay ME, Precht RJ (2017) Targeting biofilms of multidrug-resistant bacteria with silver oxynitrate. International journal of antimicrobial agents. 2017 June; doi: https://doi.org/10.1016/j.ijantimicag.2017.01.019
  • Lemire JA, Kalan L, Gugala N, Bradu A, Turner RJ (2017) Silver oxynitrate – an efficacious compound for the prevention and eradication of dual-species biofilms. Biofouling. 2017 April; doi: https://doi.org/10.1080/08927014.2017.1322586
  • Lemire J, Chatfield-Reed K, Kalan L, Gugala N, Westersund, Almblad H, Chua G, Turner RJ (2017) Unravelling the myths and mysteries of the antimicrobial agent, silver. The FASEB Journal. 2017 April; doi: https://doi.org/10.1096/fasebj.31.1_supplement.939.2
  • Loesche M, Gardner SE, Kalan L, Horwinski J, Zheng Q, Hodkinson BP, Tyldsley AS, Franciscus CL, Killis SL, Mehta S, Margolis DJ, Grice EA (2016) Temporal stability in chronic wound microbiota is associated with poor healing. Journal of Investigative Dermatology. 2016 December; doi: https://doi.org/10.1016/j.jid.2016.08.009
  • Kalan L, Gardner SE, Grice EA (2016) Reply to “Understanding the Role of Fungi in Chronic Wounds”. MBio. 2016 December; doi: https://doi.org/10.1128/mBio.02033-16
  • Kalan L, Loesche M, Hodkinson BP, Heilmann K, Ruthel G, Gardner SE, Grice EA (2016) Redefining the Chronic-Wound Microbiome: Fungal Communities Are Prevalent, Dynamic, and Associated with Delayed Healing. MBio. 2016 September; doi: https://doi.org/10.1128/mBio.01058-16
  • Kalan L, Loesche M, Horwinski J, Hodkinson B, Gardner S, Grice E (2016) THE FUNGAL COMMUNITIES OF DIABETIC FOOT ULCERS. Wound Repair and Regeneration. 2016 March.
  • Swanson T, Angel D, Sussman G, Cooper R, Haeslet E, Ouset K, Carville K, Fletcher J, Kalan L, Keast D, Leaper DJ, Schultz G, Black J, Call E (2016) Wound infection in clinical practice: principles of best practice. Wounds International. 2016 December; doi: http://eprints.hud.ac.uk/id/eprint/30637
  • Zhu XM, Hackl S, Thaker MN, Kalan L, Weber C, Urgast DS, Krupp EM, Brewer A, Vanner S, Szawiola A, Yim G, Feldmann J, Bechthold A, Wright GD, Zechel DL (2015) Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA-Specified Leu-tRNA(UUA) Molecule. ChemBioChem. 2015 November; doi: https://doi.org/10.1002/cbic.201500402
  • Lemire JA, Kalan L, Bradu A, Turner RJ (2015) Silver oxynitrate, an unexplored silver compound with antimicrobial and antibiofilm activity. Antimicrobial agents and chemotherapy. 2015 June; doi: https://doi.org/10.1128/AAC.05177-14
  • Frasch HJ, Kalan L, Kilian R, Martin T, Wright GD, Stegmann E (2015) Alternative Pathway to a Glycopeptide-Resistant Cell Wall in the Balhimycin Producer Amycolatopsis balhimycina. ACS Infectious Diseases. 2015 May; doi: https://doi.org/10.1021/acsinfecdis.5b00011
  • Thaker MN, Kalan L, Waglechner N, Eshaghi A, Patel SN, Poutanen S, Willey B, Coburn B, McGeer A, Low DE, Wright GD (2015) Vancomycin-variable enterococci can give rise to constitutive resistance during antibiotic therapy. Antimicrobial Agents Chemotherapy. 2015 February; doi: https://doi.org/10.1128/AAC.04490-14
  • Yim G, Kalan L, Koteva K, Thaker MN, Waglechner N, Tang I, Wright GD (2014) Harnessing the synthetic capabilities of glycopeptide antibiotic tailoring enzymes: characterization of the UK-68,597 biosynthetic cluster. ChemBioChem. 2014 September; doi: https://doi.org/10.1002/cbic.201402179
  • Szakacs TA, Kalan L, McConnell MJ, Eshaghi A, Shahinas D, McGeer A, Wright GD, Low DE, Patel SN (2014) Outbreak of vancomycin-susceptible Enterococcus faecium containing the wild-type vanA gene. Journal of Clinical Microbiology. 2014 April; doi: https://doi.org/10.1128/JCM.03563-13
  • Kalan L, Perry J, Koteva K, Thaker M, Wright G (2013) Glycopeptide sulfation evades resistance. Journal of Bacteriology. 2013 December; doi: https://doi.org/10.1128/JB.01617-12
  • Kalan L, Gessner A, Thaker MN, Waglechner N, Zhu X, Szawiola A, Bechthold A, Wright GD, Zechel DL (2013) A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene. Chemistry & biology. 2013 October; doi: https://doi.org/10.1016/j.chembiol.2013.09.006
  • McArthur AG, Waglechner N, Nizam F, Yan A, Azad MA, Baylay AJ, Bhullar K, Canova MJ, De Pascale G, Ejim L, Kalan L, King AM, Koteva K, Morar M, Mulvey MR, O’Brien JS, Pawlowski AC, Piddock LJ, Spanogiannopoulos P, Sutherland AD, Tang I, Taylor PL, Thaker M, Wang W, Yan M, Yu T, Wright GD (2013) The comprehensive antibiotic resistance database. Antimicrobial Agents Chemotherapy. 2013 June; doi: https://doi.org/10.1016/j.chembiol.2013.09.006
  • Kalan LR (2012) EXPLOITING GLYCOPEPTIDES TAILORING ENZYMES AS AN APPROACH TO OVERCOME RESISTANCE. Open Access Dissertations and Theses. 2012 October; http://hdl.handle.net/11375/12331
  • Shi R, Munger C, Kalan L, Sulea T, Wright GD, Cygler M (2012) Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffold. Proceedings of the National Academy of Sciences. 2012 July; doi: https://doi.org/10.1073/pnas.1205377109
  • D’Costa VM, King CE, Kalan L, Morar M, Sung WW, Schwarz C, Froese D, Zazula G, Calmels F, Debruyne R, Golding GB, Poinar HN, Wright GD (2011) Antibiotic resistance is ancient. Nature. 2011 August; doi: https://doi.org/10.1038/nature10388
  • Kalan L, Wright GD (2011) Antibiotic adjuvants: multicomponent anti-infective strategies. Expert reviews in molecular medicine. 2011 February; doi: 10.1017/S1462399410001766
  • Kalan L, Ebert S, Kelly T, Wright GD (2009) Noncanonical vancomycin resistance cluster from Desulfitobacterium hafniense Y51. Antimicrobial Agents Chemotherapy. 2009 July; doi: https://doi.org/10.1128/AAC.01408-08