Publications

  • Kalan L, Meisel J, Loesche M, Horwinski J, Chen X, Uberoi A, Gardner S, Grice E (2018) The microbial basis of impaired wound healing: differential roles for pathogens, “bystanders”, and strain-level diversification in clinical outcomes. bioRxiv 427567. In press: Cell Host & Microbe.
  • Kalan L, Brennan M (2018) The Role of the Microbiome in Nonhealing Diabetic Wounds. Antimicobial Therapeutics Reviews. NYAS. https://doi.org/10.1111/nyas.13926 Pubmed Record
  • Kalan L, Grice E (2017) Fungi in the Wound Microbiome. Advances in Wound Care Critical Review. https://doi.org/10/1089/wound.2017.0756 Pubmed Record
  • Kalan L, Zhou M, Labbie M, Willing B (2017) Measuring the microbiome of chronic wounds with use of a topical antimicrobial dressing – A feasibility study. PLoS ONE 12(11):e0187728 (PMC5695787) Pubmed Record
  • Lemire JA, Kalan L, Gugala N, Bradu A, Turner RJ (2017) Silver oxynitrate – an efficacious compound for the prevention and eradication of dual-species biofilms. Biofouling 33(6):460-469 Pubmed Record
  • Kalan LR, Pepin DM, Ul-Haq I, Miller SB, Hay ME, Precht RJ (2017) Targeting biofilms of multidrug-resistant bacteria with silver oxynitrate. Int. J. Antimicrob. Agents 49(6):719-726 Pubmed Record
  • Kalan L, Gardner SE, Grice EA (2016) Reply to “Understanding the Role of Fungi in Chronic Wounds”. MBio 7(6): (PMC5142625) Pubmed Record
  • Loesche M, Gardner SE, Kalan L, Horwinski J, Zheng Q, Hodkinson BP, Tyldsley AS, Franciscus CL, Hillis SL, Mehta S, Margolis DJ, Grice EA (2016) Temporal Stability in Chronic Wound Microbiota Is Associated With Poor Healing. J. Invest. Dermatol. 137(1):237-244 (PMC5279919) Pubmed Record
  • Kalan L, Loesche M, Hodkinson BP, Heilmann K, Ruthel G, Gardner SE, Grice EA (2016) Redefining the Chronic-Wound Microbiome: Fungal Communities Are Prevalent, Dynamic, and Associated with Delayed Healing. MBio 7(5): (PMC5013295) Pubmed Record
  • Zhu XM, Hackl S, Thaker MN, Kalan L, Weber C, Urgast DS, Krupp EM, Brewer A, Vanner S, Szawiola A, Yim G, Feldmann J, Bechthold A, Wright GD, Zechel DL (2015) Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA-Specified Leu-tRNA(UUA) Molecule. Chembiochem 16(17):2498-506 Pubmed Record
  • Frasch HJ, Kalan L, Kilian R, Martin T, Wright GD, Stegmann E (2015) Alternative Pathway to a Glycopeptide-Resistant Cell Wall in the Balhimycin Producer Amycolatopsis balhimycina. ACS Infect Dis 1(6):243-52 Pubmed Record
  • Lemire JA, Kalan L, Bradu A, Turner RJ (2015) Silver oxynitrate, an unexplored silver compound with antimicrobial and antibiofilm activity. Antimicrob. Agents Chemother. 59(7):4031-9 (PMC4468715) Pubmed Record
  • Thaker MN, Kalan L, Waglechner N, Eshaghi A, Patel SN, Poutanen S, Willey B, Coburn B, McGeer A, Low DE, Wright GD (2014) Vancomycin-variable enterococci can give rise to constitutive resistance during antibiotic therapy. Antimicrob. Agents Chemother. 59(3):1405-10 (PMC4325790) Pubmed Record
  • Yim G, Kalan L, Koteva K, Thaker MN, Waglechner N, Tang I, Wright GD (2014) Harnessing the synthetic capabilities of glycopeptide antibiotic tailoring enzymes: characterization of the UK-68,597 biosynthetic cluster. Chembiochem 15(17):2613-23 Pubmed Record
  • Szakacs TA, Kalan L, McConnell MJ, Eshaghi A, Shahinas D, McGeer A, Wright GD, Low DE, Patel SN (2014) Outbreak of vancomycin-susceptible Enterococcus faecium containing the wild-type vanA gene. J. Clin. Microbiol. 52(5):1682-6 (PMC3993680) Pubmed Record
  • Kalan L, Gessner A, Thaker MN, Waglechner N, Zhu X, Szawiola A, Bechthold A, Wright GD, Zechel DL (2013) A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene. Chem. Biol. 20(10):1214-24 Pubmed Record
  • McArthur AG, Waglechner N, Nizam F, Yan A, Azad MA, Baylay AJ, Bhullar K, Canova MJ, De Pascale G, Ejim L, Kalan L, King AM, Koteva K, Morar M, Mulvey MR, O’Brien JS, Pawlowski AC, Piddock LJ, Spanogiannopoulos P, Sutherland AD, Tang I, Taylor PL, Thaker M, Wang W, Yan M, Yu T, Wright GD (2013) The comprehensive antibiotic resistance database. Antimicrob. Agents Chemother. 57(7):3348-57 (PMC3697360) Pubmed Record
  • Kalan L, Perry J, Koteva K, Thaker M, Wright G (2012) Glycopeptide sulfation evades resistance. J. Bacteriol. 195(1):167-71 (PMC3536170) Pubmed Record
  • Shi R, Munger C, Kalan L, Sulea T, Wright GD, Cygler M (2012) Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffold. Proc. Natl. Acad. Sci. U.S.A. 109(29):11824-9 (PMC3406828) Pubmed Record
  • D’Costa VM, King CE, Kalan L, Morar M, Sung WW, Schwarz C, Froese D, Zazula G, Calmels F, Debruyne R, Golding GB, Poinar HN, Wright GD (2011) Antibiotic resistance is ancient. Nature 477(7365):457-61 Pubmed Record
  • Kalan L, Wright GD (2011) Antibiotic adjuvants: multicomponent anti-infective strategies. Expert Rev Mol Med 13:e5 Pubmed Record
  • Kalan L, Ebert S, Kelly T, Wright GD (2009) Noncanonical vancomycin resistance cluster from Desulfitobacterium hafniense Y51. Antimicrob. Agents Chemother. 53(7):2841-5 (PMC2704641) Pubmed Record